The iarc tp53 database
WebThe IARC TP53 database is a public web-based resource for the analysis and interpretation of the biological and clinical impacts of TP53 gene variations in human cancers (http://www-p53.iarc.fr/). It contains data that are compiled from the peer-reviewed scientific literature or generalist databases. WebTP53 variants were analyzed using the IARC (www-p53.iarc.fr) and the UMD TP53 mutation databases (p53.free.fr). Each TP53 variant was validated by TP53_MUT_ASSESSOR, a multicriteria algorithm specifically developed for the analysis of TP53 mutation and based on the 2015 issue of the UMD TP53 database containing 60,000 TP53 mutations. 13
The iarc tp53 database
Did you know?
WebThe TP53 Database compiles various types of data and information from the literature and generalist databases on human TP53 gene variations related to cancer. The database is … The database includes various annotations on the predicted or experimentally … TumorVariantDownload_r20.csv. This dataset contains TP53 tumor variants … To assess TP53 variant status it is recommended to perform gene … The TP53 Database; About; User Manual; Other Resources; Events; Release Notes; … For information about TP53 database releases, see Database Development on … Search by Gene Variants - The TP53 Database ISB-CGC Tumor Variants Explore data for TP53 tumor variants identified in human tumor … Functional / Structural Data - The TP53 Database ISB-CGC Cell Lines Explore data for cell-lines that have been screened for TP53 variant and … Search Germline Variant Data - The TP53 Database ISB-CGC WebFeb 1, 2007 · All TP53 gene variations (somatic and germline mutations, as well as polymorphisms) that are reported in the scientific literature or in SNP databases are compiled in the IARC TP53 Database.
WebThe database compiles all mutations (somatic and inherited), as well as polymorphisms, that have been reported in the published literature since 1989. The IARC TP53 mutation … WebJan 1, 2024 · The IARC TP53 web site ( http://www-p53.iarc.fr) provides a search interface for the core database and includes a comprehensive user guide, a slide-show on TP53 …
WebApr 22, 2016 · TP53 mutational status (exon 5-8), with structural classification of single nucleotide variations according to the IARC-TP53-Database, methylation status of MIR34A/B/C and DAPK, and p53-protein expression were assessed. WebIn patients with HCC, TP53 hotspot mutations with a frequency of 1% and higher mainly include R249S, R248Q, Y220C, and V157F [17], and TP53 Y220C mutation has been identified in HCC (1% frequency ...
WebNov 3, 2024 · The TP53 gene is the most commonly mutated gene in a wide variety of human cancers and the functions of the wild-type p53 protein are frequently compromised in many types of cancers. 1 The ...
WebSomatic mutations in the TP53 gene are one of the most frequent alterations in human cancers, and germline mutations are the underlying cause of Li-Fraumeni syndrome, which predisposes to a wide spectrum of early-onset cancers. Most mutations are single-base substitutions distributed throughout the … foschini the glen mallWebExplore data for cell-lines that have been screened for TP53 variant and have been published in the scientific literature, in the Sanger cell-line database, or the Broad Cancer cell-line Encyclopedia . Search Cell-Line Data Allows the retrieval and analysis of TP53 mutations reported in human cell-lines. foschini the crossing mafikengWebJun 22, 2016 · TP53 gene mutations are one of the most frequent somatic events in cancer. The IARC TP53 Database ( http://p53.iarc.fr) is a popular resource that compiles … foschini the glen contact details