Web1. mar 2024 · Phenytoin clearance is decreased slightly in elderly patients and lower or less frequent dosing may be required [see Clinical Pharmacology (12.3)]. Dosing during Pregnancy Decreased serum concentrations of phenytoin may occur during pregnancy because of altered phenytoin pharmacokinetics. Web1. jún 2016 · The clinical implication of Michaelis-Menten pharmacokinetics is that the clearance of phenytoin is not a constant as it is with linear pharmacokinetics, but is …

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WebThe effect of cimetidine on the disposition kinetics of phenytoin was investigated in 7 healthy volunteers. Each subject received a single intravenous dose of phenytoin on two … WebPhenytoin is used in the management of generalized tonico-clonic and complex partial seizures. It may also be used in the prevention of seizures following head trauma, and in … omega 3 good for masculars

Why does clearance increase after phenytoin overdose?

Web19. okt 2024 · The estimated phenobarbital clearance and volume of distribution ranged from 0.0034 to 0.0104 L/h/kg and 0.37 to 1.21 L/kg, respectively, with body weight, age, and concomitant antiepileptic drugs being the three most frequently identified predictors of clearance. ... Co-administration of phenobarbital with phenytoin, carbamazepine, or … WebMost therapeutic drug monitoring (TDM) packages are based on the maximum a posteriori (MAP) estimation. In this study, HMCtdm, a new TDM package, was developed using a Hamiltonian Monte Carlo (HMC) simulation. The estimation process of HMCtdm for the drugs amikacin, vancomycin, theophylline, and phenytoin was based on the R package … Web19. nov 2010 · In a small pharmacokinetic study, phenytoin clearance was reduced by 30% when combined with TMP [12]. Given the saturable nature of phenytoin metabolism, decreases in phenytoin clearance of this magnitude may lead to clinically significant increases in phenytoin concentrations. omega 3 for skin health