WebHMGCR-associated IMNM is a rare subset of myositis. With systemic treatment, patients usually achieve partial or complete remission. Optimal treatment has not been … WebHMGCR is a glycoprotein catalyzing the conversion of HMG-CoA to mevalonic acid, an essential step in cholesterol biosynthesis [30,31]. HMGCR is inhibited by statins (HMGCR inhibitors), which suppress serum cholesterol levels and markedly reduce overall cardiovascular events [32].

Myopathy with anti-HMGCR antibodies Neurology …

WebMay 1, 2024 · Anti-HMGCR myositis is usually a chronic disease requiring long-term immunosuppression. Although younger patients had more severe disease and a worse prognosis than older patients, they did not have evidence of a known co-existing muscular dystrophy to explain their persistent, and sometimes progres … WebHowever, it is often especially effective for patients with refractory dermatomyositis skin symptoms and patients with interstitial lung disease. Some physicians also use IVIg alone as first-line therapy in patients who have necrotizing myopathy … nic showalter

Necrotizing Myopathy - The Myositis Association

WebIn these cases, the patients are still classified as having anit-HMGCR myositis with a DM-like rash. 59. Atypical Clinical Presentation. While the vast majority of patients present … WebFeb 18, 2016 · Hamann PD, Cooper RG, McHugh NJ, Chinoy H. Statin-induced necrotizing myositis — a discrete autoimmune entity within the “statin-induced myopathy spectrum.” … WebApr 15, 2024 · Anti-HMGCR was positive. Based on clinical presentation and laboratory test findings, et al. diagnosis of autoimmune myositis, secondary to tozinameran immunisation was made. Therefore, the man was treated with unspecified oral steroids and immune-globulins. As a result, complete resolution of autoimmune myositis was noted within 4 … nics hours