Dexrazoxane used with doxorubicin
WebDexrazoxane should only be used in adult patients with advanced or metastatic breast cancer. The benefits of dexrazoxane do not outweigh its risks in children and adolescents. Dexrazoxane should only be used in adult patients who have already received a minimum cumulative anthracycline dose of 300 mg/m 2 of doxorubicin, or 540 mg/m 2 of epirubicin. WebAug 16, 2024 · The suggested dosage ratio of dexrazoxane to doxorubicin is 10 to 1 (e.g., 500 mg/m^2 dexrazoxane to 50 mg/m^2 doxorubicin). It is advisable to give dexrazoxane before doxorubicin. ... The common side effects that culminate from dexrazoxane use include dose-limiting myelotoxicity (neutropenia, leukopenia, granulocytopenia, and …
Dexrazoxane used with doxorubicin
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WebJun 1, 2024 · Dexrazoxane for injection, a cardioprotective agent for use in conjunction with doxorubicin, is a sterile, pyrogen-free lyophilizate … WebJan 29, 2024 · Dexrazoxane protects against the cardiotoxic effects of anthracyclines, but in the USA and some European countries, its use had been restricted to adults with …
WebThere is some evidence that the use of dexrazoxane concurrently with the initiation of fluorouracil, doxorubicin, and cyclophosphamide (FAC) therapy interferes with the antitumor efficacy of the regimen, and this use is not recommended. ... The recommended dosage ratio of ZINECARD:doxorubicin is 10:1 (e.g., 500 mg/m2 ZINECARD:50 mg/m2 ... WebJul 19, 2024 · 1 INDICATIONS AND USAGE. Dexrazoxane for injection is indicated for reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose of 300 mg/m 2 and who will continue to receive doxorubicin therapy …
Dexrazoxane injection is available as 2 different products that are used to treat or prevent certain side effects that may be caused by certain chemotherapy medications. Dexrazoxane injection (Zinecard) is used to prevent or decrease heart damage caused by doxorubicin in women who are taking the medication … See more Some people who took a medication that is very similar to dexrazoxane injection developed new forms of cancer. There is not enough information to tell if receiving dexrazoxane … See more It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as … See more Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to dexrazoxane injection. Ask your doctor or pharmacist any questions you have about … See more WebMar 16, 2024 · In children with cancer, giving dexrazoxane (Zinecard) before each dose of doxorubicin decreases the risk of treatment-related heart problems in adulthood, a new …
WebCOMMON BRAND NAME (S): Zinecard. USES: Dexrazoxane is used to reduce the risk and severity of heart damage caused by doxorubicin treatment and similar cancer …
WebJan 12, 2024 · The Totect brand of dexrazoxane is used in men or women to treat a condition called extravasation (es-TRA-va-ZAY-shun). Extravasation happens when an … daily grind lower water streetWebDexrazoxane is used to reduce the risk and severity of heart damage caused by doxorubicin treatment and similar cancer chemotherapy medications. Heart damage limits the length of time you can be ... bio house bolognaWebDoxorubicin is used in combination with other medications to treat certain types of bladder, breast, lung, stomach, and ovarian cancer; Hodgkin's lymphoma (Hodgkin's disease) and … daily grind lunch menuWebZinecard ® (dexrazoxane for injection) DESCRIPTION ZINECARD ® (dexrazoxane for injection) is a sterile, pyrogen-free lyophilizate intended for intravenous administration. It … daily grind london bridgeWebSummary. Dexrazoxane is a cytoprotective drug used to prevent and improve cardiomyopathy associated with doxorubicin treatment for metastatic breast cancer. Brand Names. Savene, Totect, Zinecard. Generic Name. Dexrazoxane. DrugBank Accession Number. DB00380. daily grind marshall mnWebINTRODUCTION. Doxorubicin (DOX) is a potent chemotherapy and widely used for many cancer types. However, it may lead to cardiac toxicity when used chronically or in a high dose, leading to myocardial dysfunction in cancer patients.[] Recently, DOX is also found to elicit hepatic and renal toxicity,[2,3] raising more concern for DOX chemotherapy … daily grind marshfield wiWebDexrazoxane has been used in combination of doxorubicin to prevent heart failure. Schwartz et al used dexrazoxane as a cardioprotection to enable the use of higher cumulative dose of doxorubicin in children with osteosarcoma, cumulative dose of doxorubicin of 450 to 600 mg/m 2 was used. Out of 242 patients, only 5 developed … biohouse seminar uw madison