WebIn this review, we comprehensively discuss the expression of CTGF and its regulation, oncogenic role, clinical relevance, targeting strategies, and therapeutic agents. Herein, … WebSep 11, 2024 · Although the YAP target CTGF was decreased after Ras transformation in MCF10A cells, increased expression is seen after HRas G12V expression in HEK293T cells 25.
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WebMar 18, 2010 · Connective tissue growth factor (CTGF) is a profibrogenic factor that stimulates fibroblast proliferation, cell adhesion, and extracellular matrix production (9,10). The potential role of CTGF in pathological fibrosis has been established , and CTGF has been suggested to be an attractive therapeutic target in some fibrotic diseases . Several clinical trials are now ongoing that investigate the therapeutic value of targeting CTGF in fibrosis, diabetic nephropathy, and pancreatic cancer. CTGF (CCN2) has recently been implicated in mood disorders, notably in the postpartum period; these effects may be mediated by its effects on … See more CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein). … See more Members of the CCN protein family, including CTGF, are structurally characterized by having four conserved, cysteine-rich domains. These domains are, from N- to C-termini, the insulin-like growth factor binding protein (IGFBP) domain, the von … See more • Ctgf/hcs24 CAESAR • CYR61 (CCN1) See more • Human CTGF genome location and CTGF gene details page in the UCSC Genome Browser. See more Knockout mice with the Ctgf gene disrupted die at birth due to respiratory stress as a result of severe chondrodysplasia. … See more CTGF is associated with wound healing and virtually all fibrotic pathology. It is thought that CTGF can cooperate with TGF-β to induce sustained fibrosis and to exacerbate extracellular matrix production in association other fibrosis-inducing conditions. … See more canon mg3650 light flashing
Anti-CTGF Antibodies Invitrogen - Thermo Fisher Scientific
WebApr 12, 2024 · Gene expression analysis showed that USP1 depletion further decreased the expression of CTGF and CYR61, which are the most classical Hippo target genes, in HLF and Hep3B cells (Fig. 2C, G), while ... WebOct 29, 2024 · CTGF and TGFβ were found to be increased in the alveolar epithelial cells inoculated with SARS-CoV-2 (Xu et al., 2024). As a … WebThe CTGF gene is a transcriptional target of both YAP/TAZ and TGFβ-SMAD signaling pathways (6,7), and aberrant regulation of CTGF expression is strongly associated with pathological conditions, notably cancer and fibrosis (8,9). Chen, C.C. and Lau, L.F. (2009) Int J Biochem Cell Biol 41, 771-83. flagstaff az hospital phone number