Ctgf fg-3019
WebApr 26, 2024 · また、膵臓がんと肺線維症では既にCTGFに対する抗体であるFG-3019(pamrevlumab)による治療が臨床治験の第2段階まで進んでいる。 さらに研究チームは、FG-3019の中皮腫に対する効果を検証する実験を、前臨床試験として細胞培養レベル、動物レベルで実施した。 WebFeb 1, 2011 · The FG-3019 binding epitope overlaps with the VWC domain of connective tissue growth factor (CTGF).(A) The region of the FG-3019 binding epitope (CTGF amino acids 142 to 157, indicated in yellow) is superimposed on the structure of the collagen IIa VWC domain [].By sequence homology, the general structural features of this domain …
Ctgf fg-3019
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WebSep 28, 2024 · Connective tissue growth factor (CTGF) is a secreted glycoprotein that has a central role in the process of fibrosis. This study was designed to assess the safety, tolerability, and efficacy of pamrevlumab … WebFG-3019 is a fully human monoclonal antibody specific for CTGF. Pre-clinical studies suggest that FG-3019 penetrates into tissues to reduce effective tissue levels of CTGF resulting in reduction of pro-fibrotic factors, enabling a rebalancing of ECM secretion and processing, and a return toward tissue homeostasis. In a mouse model of radiation ...
WebSep 4, 2024 · To evaluate the effect of CTGF inhibition, 40 mg/kg FG-3019 or hIgG was intraperitoneally administered twice per week from the day of inoculation. The length and width of the xenograft tumors were measured twice per week, and the tumor volume was calculated according to the following formula: tumor volume = 1/2 × (major axis) × (minor … WebAnti-CTGF Antibody Therapy with FG-3019 Reverses Diabetes-Induced Cardiovascular Complications in Streptozotocin (STZ) Treated Rats Cardiovascular disease is a le …
WebAug 6, 2024 · Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other growth factors and promotes kidney fibrosis. ... Of these, FG-3019, a human monoclonal antibody to CTGF, has been used in some animal models, including pulmonary fibrosis, … WebCTGF gilt als zentraler Signalgeber bei der bindegewebigen Umwandlung von Lungengewebe. Bei einem Start der Behandlung 16 Wochen nach Radiatio machte der monoklonale Antikörper FG-3019 gegen CTGF fibrotische Umwandlungen rückgängig.
WebNov 17, 2015 · Trial of Pamrevlumab (FG-3019), a Monoclonal Antibody to Connective Tissue Growth Factor, in Non-Ambulatory Subjects With Duchenne Muscular Dystrophy: …
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