WebCompared with younger mice, injured DRG sensory neurons in older mice expressed higher levels of the chemokine CXCL13, which attracted CXR5 + CD8 + T cells. T cell–neuron cross-talk activated caspase 3, which impaired pAKT, and pS6 signaling causing regenerative failure. When caspase 3, CXCR5, or CXCL13 was therapeutically targeted, … WebRecently, the chemokine CXCL13 has been shown to be expressed in 90% of AILTCL, but only in 10% of peripheral T-cell lymphoma, NOS. Disrupted and expanded FDC networks can be recognized using antibodies to CD21, CD35, and clusterin, a feature that helps to …
Chemokine CXCL13 - an overview ScienceDirect Topics
WebSep 12, 2024 · CXCL13 is a chemokine that is widely involved in the pathogenesis of autoimmune diseases, tumors and inflammatory diseases. In this study, we investigate the role of CXCL13 in the pathogenesis of inflammatory bowel disease using both clinical specimens and animal models. We found that the serum CXCL13 concentration in IBD … WebAug 9, 2024 · CXCL13 (chemokine (C-X-C motif) ligand 13) is a B cell chemokine demonstrated to drive aggregate formation in tertiary lymphoid structures in mouse models of AAD , and CXCL12 has been demonstrated to be important in distinct lung inflammatory models . MMP-12 can modulate the activity of CXC chemokines by proteolytic processing . how to unsubscribe from crunchyroll premium
Chemokine CXCL13 in serum, CSF and blood–CSF barrier …
WebSep 12, 2024 · Introduction. C-X-C motif chemokine ligand 13 (CXCL13), also known as B cell attracting chemokine (BCA-1) or B lymphocyte chemoattractant (BLC), is a kind of chemokine that was originally identified in stromal cells of B cell follicles that regulates the homing of B cells and T cells subsets ().It is widely involved in the pathogenesis of … WebFeb 24, 2024 · The CXCL13 negative CSF category was divided into two subgroups, 10 samples with normal QAlb (< 30/N) and 12 samples with pathological QAlb (< 30/P). Table 1 summarizes median CXCL13 concentrations in CSF and serum, the resultant Qcxcl13 … WebCXCL13/BLC/BCA-1 is a constitutively expressed chemokine that plays an important role in B and T cell homing. It is expressed by salivary gland epithelium, dendritic cells, osteoclasts, and peritoneal macrophages. It … how to unsubscribe from cred